niclosamide

95%tech, 75%wp,

Molluscicide

NOMENCLATURE

niclosamide

Common name niclosamide (BSI, E-ISO, (m) F-ISO, BAN, Germany (for veterinary use))

IUPAC name 2',5-dichloro-4'-nitrosalicylanilide 

Chemical Abstracts name 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide 

CAS RN [50-65-7]  Development codes Bayer 25 648; Bayer 73; SR 73 

PHYSICAL CHEMISTRY

niclosamide

Mol. wt. 327.1  M.f. C13H8Cl2N2O4  Form Almost colourless crystals.  M.p. 230 ºC  V.p. <1 mPa (20 ºC)  KOW logP = 1 (pH 9.6)  Solubility In water 1.6 (pH 6.4), 110 (pH 9.1) (both in mg/l, 20 ºC). Soluble in common organic solvents such as ethanol and diethyl ether.  Stability Hydrolysed in aqueous solution, DT50 (20 ºC) c. 7 d (pH 6.9), 18.8 d (pH 13.3). Stable to heat. Decomposes under u.v. irradiation. Hydrolysed by concentrated acid or alkali. 

APPLICATIONS

niclosamide

Mode of action Molluscicide with respiratory and stomach action.  Uses Control of golden apple snail in rice. Control of schistosomiasis and fascioliasis in man by killing fresh-water snails which act as intermediate hosts. Also used for veterinary control of tapeworm infestations.  Formulation types EC.  Compatibility Incompatible with acidic materials.

product name:	niclosamide 95% tech	niclosamide 75% wp
appearance:	pale yellow loosen  powder	yellow loosen  powder
a.i. content:	95.02%	75.02%
ph value:	6.3	8.7
water:	0.10%	/
suspensibility:	/	88%
wettability:	/	50(s)
fineness:	/	99%